Shop the hottest Mens Custom San Francisco 49ers Nike Game Jerseys at Fanatics.com. These jerseys are designed with fan comfort in mind. Custom 49ers Mens Nike Game Jerseys feature mesh panels for breathability, twill jock tag, screen-printed numbers and name, and a tailored design for movement. Game jerseys are perfect for any budget. Showcase your Niners pride with a brand new Nike Game Jersey from Fanatics.com.